Engineering protein particles for pulmonary drug delivery.

摘要: Pulmonary delivery of proteins requires particles for to be in the aerodynamic size range 1–5 μm deep lung deposition. However, traditional particle reduction technique jet-milling normally used inhalation is not suitable processing these protein because their lability brought about by weak physical interactions making up higher order structures. Advanced techniques such as spray drying, freeze drying and use supercritical fluid technology have been developed produce morphology long deposition without altering native conformation biomolecules. Judicious excipients operating conditions are some factors needed a successful design.