Epigenetics as a novel therapeutic target of cancer

摘要: Epigenetic therapy is highly anticipated as a next player to molecular target drugs. abnormalities are maintained even after somatic cell division, and can be causally involved in carcinogenesis. Recent cancer genome analysis revealed that significant fraction of cancers cannot accounted for only by mutations known protein-coding genes, epigenetic genes unexpectedly frequent. DNA demethylating drugs histone deacetylase inhibitors already approved, many next-generation under development. Application therapies solid tumors being attempted, promising result available non-small lung cancers. Right patients, right doses, combinations key further success, done based on recent progresses mechanistic analyses.