Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes.
作者： Rebecca C. J. Twells , Charles A. Mein , Felicity Payne , Riitta Veijola , Matthew Gilbey
DOI: 10.1007/S00439-003-0940-6
关键词:
摘要: Linkage of chromosome 11q13 to type 1 diabetes (T1D) was first reported from genome scans (Davies et al. 1994; Hashimoto 1994) resulting in P T. The disease association data, largely focused the LRP5 region with 1,106 T1D families, provided no further evidence for at or D11S987. A second dataset, comprising 1,569 families Finland, failed replicate our previous findings LRP5. continued search variants putative IDDM4 locus will greatly benefit future development a haplotype map genome.
springer.com
sci-hub.se 参考文章(40)
A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions. American Journal of Human Genetics. ,vol. 69, pp. 1301- 1313 ,(2001) , 10.1086/324341
Marcel Wehrli, Scott T. Dougan, Kim Caldwell, Louise O'Keefe, Stephanie Schwartz, Dalit Vaizel-Ohayon, Eyal Schejter, Andrew Tomlinson, Stephen DiNardo, arrow encodes an LDL-receptor-related protein essential for Wingless signalling Nature. ,vol. 407, pp. 527- 530 ,(2000) , 10.1038/35035110
Mark J. Daly, John D. Rioux, Stephen F. Schaffner, Thomas J. Hudson, Eric S. Lander, High-resolution haplotype structure in the human genome. Nature Genetics. ,vol. 29, pp. 229- 232 ,(2001) , 10.1038/NG1001-229
A. Sniderman, D. Thomas, D. Marpole, B. Teng, Low Density Lipoprotein Journal of Clinical Investigation. ,vol. 61, pp. 867- 873 ,(1978) , 10.1172/JCI109012
Iain A. Eaves, Simon T. Bennett, Peter Forster, Karin M. Ferber, David Ehrmann, Amanda J. Wilson, Sumit Bhattacharyya, Anette-G. Ziegler, Bernd Brinkmann, John A. Todd, Transmission ratio distortion at the INS-IGF2 VNTR. Nature Genetics. ,vol. 22, pp. 324- 325 ,(1999) , 10.1038/11890
Gillian C.L. Johnson, Laura Esposito, Bryan J. Barratt, Annabel N. Smith, Joanne Heward, Gianfranco Di Genova, Hironori Ueda, Heather J. Cordell, Iain A. Eaves, Frank Dudbridge, Rebecca C.J. Twells, Felicity Payne, Wil Hughes, Sarah Nutland, Helen Stevens, Phillipa Carr, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Stephen C.L. Gough, David G. Clayton, John A. Todd, Haplotype tagging for the identification of common disease genes Nature Genetics. ,vol. 29, pp. 233- 237 ,(2001) , 10.1038/NG1001-233
John D. Rioux, Mark J. Daly, Mark S. Silverberg, Kerstin Lindblad, Hillary Steinhart, Zane Cohen, Terrye Delmonte, Kerry Kocher, Katie Miller, Sheila Guschwan, Edward J. Kulbokas, Sinead O'Leary, Ellen Winchester, Ken Dewar, Todd Green, Valerie Stone, Christine Chow, Albert Cohen, Diane Langelier, Gilles Lapointe, Daniel Gaudet, Janet Faith, Nancy Branco, Shelley B. Bull, Robin S. McLeod, Anne M. Griffiths, Alain Bitton, Gordon R. Greenberg, Eric S. Lander, Katherine A. Siminovitch, Thomas J. Hudson, Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nature Genetics. ,vol. 29, pp. 223- 228 ,(2001) , 10.1038/NG1001-223
Kathleen I. Pinson, Jane Brennan, Susan Monkley, Brian J. Avery, William C. Skarnes, An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. ,vol. 407, pp. 535- 538 ,(2000) , 10.1038/35035124
Keiko Tamai, Mikhail Semenov, Yoichi Kato, Rebecca Spokony, Chunming Liu, Yu Katsuyama, Fred Hess, Jean-Pierre Saint-Jeannet, Xi He, LDL-receptor-related proteins in Wnt signal transduction Nature. ,vol. 407, pp. 530- 535 ,(2000) , 10.1038/35035117
Jean-Pierre Hugot, Mathias Chamaillard, Habib Zouali, Suzanne Lesage, Jean-Pierre Cézard, Jacques Belaiche, Sven Almer, Curt Tysk, Colm A. O'Morain, Miquel Gassull, Vibeke Binder, Yigael Finkel, Antoine Cortot, Robert Modigliani, Pierre Laurent-Puig, Corine Gower-Rousseau, Jeanne Macry, Jean-Frédéric Colombel, Mourad Sahbatou, Gilles Thomas, Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Nature. ,vol. 411, pp. 599- 603 ,(2001) , 10.1038/35079107