Topoisomerase I and II inhibitors: chemical structure, mechanisms of action and role in cancer chemotherapy
作者： L G Dezhenkova , V B Tsvetkov , A A Shtil
DOI: 10.1070/RC2014V083N01ABEH004363
关键词:
摘要: The review summarizes and analyzes recent published data on topoisomerase I II inhibitors as potential antitumour agents. Functions the mechanism of action topoisomerases are considered. molecular interactions between low-molecular-weight compounds these proteins is discussed. Topoisomerase belonging to different classes chemical systematically covered. Assays for inhibition possibilities using computer-aided modelling rational design novel drugs cancer chemotherapy presented. bibliography includes 127 references.
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