The potential role of nonneuronal cells in the deep brain stimulation mechanism.

作者: Vinata Vedam-Mai , Michael S. Okun , Elly M. Hol

DOI: 10.1007/978-3-642-30991-5_19

关键词:

摘要: Deep brain stimulation (DBS) is the surgical therapy of choice for a variety treatment-resistant movement disorders, and many neuropsychiatric disorders. However, mode action DBS still unclear. It unknown which neural cell types in complex circuitry are involved workings DBS, how high-frequency specific may lead to alleviation patient’s clinical symptoms. Although existing theories working rely mostly on neurons, it likely that other could be involved. known glia heavily synaptic communication through formation tripartite synapse. Recent evidence indicates can result direct activation glial cells release gliotransmitters. This turn have an effect synapse, as well downstream network activity. In this chapter we focus reviewing effects nonneuronal cells, speculate potential role DBS-mediated activation.

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