Topical use of prostacyclin in microvascular surgery
作者： David J. McK. Crabb , Margaret Niall , Kenneth R. Knight , James A. Angus , Bernard McC. O'Brien
DOI: 10.1016/0007-1226(85)90247-4
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摘要: Abstract Prostacyclin was investigated for its ability to overcome surgically induced spasm of the femoral artery and increase blood flow through rabbit epigastric free flap. Topical prostacyclin (200 ng/ml) lignocaine (20 mg/ml or 2%) each produced near-maximal vasodilatation large conducting vessels. This resulted in a significant after 5 minutes form topical treatment, compared saline control. However obtained from tended wear off over 30 minutes. Treatment with systemic indomethacin did not prevent surgical nor action relieving it. 6-oxo-prostaglandin F 1α , major breakdown metabolite prostacyclin, responsible vasodilatory prostacyclin. also caused platelet disaggregation some rebleeding anastomotic site, nevertheless there no difference flap survival between use lignocaine.
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