Chemotherapy Drugs Form Ion Pores in Membranes Due to Physical Interactions with Lipids

摘要: We demonstrate the effects on membrane of tubulin-binding chemotherapy drugs: thiocolchicoside and taxol. Electrophysiology recordings across lipid membranes in aqueous phases containing drugs were used to investigate drug conductance. Molecular dynamics simulation drug–lipid complexes was elucidate mechanism at an atomistic level. Both are observed induce stable ion-flowing pores membranes. Discrete pore current–time plots exhibit triangular conductance events contrast rectangular ones found for ion channels. simulations indicate that lipids experience electrostatic van der Waals interactions short periods time when within each other’s proximity. The energies from these two be similar derived theoretically using screened Coulomb between peptides due mainly their charge properties while forming peptide-induced channels bilayers. Experimental silico studies together suggest inside physical interactions. findings reveal cytotoxic cell membrane, which may aid novel development treatment cancer other diseases.