Metal status in human endometrium: relation to cigarette smoking and histological lesions.

摘要: Human endometrium is a thick, blood vessel-rich, glandular tissue which undergoes cyclic changes and potentially sensitive to the various endogenous exogenous compounds supplied via hematogenous route. As recently indicated, several metals including Cd, Pb, Cr Ni represent an emerging class of potential metalloestrogens can be implicated in alterations female reproductive system endometriosis cancer. In present study, we investigated content five metals: Cr, Ni, Pb Zn 25 samples human collected from Polish females undergoing diagnostic or therapeutic curettage uterine cavity. The overall mean metal concentration (analyzed using microwave induced plasma atomic emission spectrometry MIP-OES) decreased following order: Cr>Pb>Zn>Ni>Cd. For first time it was demonstrated that cigarette smoking significantly increases endometrial Cd Pb. Concentration these also positively correlated with years number smoked cigarettes. Tissue recognized histologic lesions (simple hyperplasia, polyposis atrophy) were characterized by 2-fold higher level. No relation between age women found. Our study shows target accumulation within body. Quantitative analyses could serve as additional indicator impairments menstrual cycle fertility.