Pharmacogenetics in HIV therapy.

摘要: Administration of standard doses most antiretroviral drugs results in significant variations plasma drug concentrations among different individuals, as well rates drug-associated toxicity. The reasons for the large interindividual variability levels are multifactorial, and involve differences gender metabolism, concomitant medications, compliance, underlying diseases, genetic factors. Pharmacogenetics is discipline that analyses basis variation body disposition drugs. One main goals to give grounds individualized therapy. majority pharmacogenetic traits so far have involved metabolism. An example this inherited pharmacokinetics pharmacodynamics such hydralazine or isoniazid. This due polymorphisms N-acetyltransferase-2 (NAT2) gene, which may split population into three categories: slow, intermediate, fast metabolizers. Pharmacogenetic studies conducted with antiretrovirals focused on metabolizing enzymes transporter proteins cell membrane. Herein, we review known be associated altered antiretrovirals, influence efficacy toxicity these