Large-Scale and Multiscale Networks in the Rodent Brain during Novelty Exploration.

摘要: Neural activity is coordinated across multiple spatial and temporal scales, these patterns of coordination are implicated in both healthy impaired cognitive operations. However, empirical cross-scale investigations relatively infrequent, due to limited data availability the difficulty analyzing rich multivariate datasets. Here we applied frequency-resolved source-separation analyses characterize a large-scale dataset comprising spiking local field potential recorded simultaneously three brain regions (prefrontal cortex, parietal hippocampus) freely-moving mice. We identified constellation multidimensional, inter-regional networks range frequencies (2-200 Hz). These were reproducible within animals different recording sessions, but varied animals, suggesting individual variability network architecture. The theta band (∼4-10 Hz) had several prominent features, including roughly equal contribution from all strong inter-network synchronization. Overall, findings demonstrate multidimensional landscape functional activations cortical operating spatial, spectral, scales during open-field exploration. Significance statement synchronized over space, time, frequency. To dynamics spanning regions, prefrontal hippocampus awake behaving mice, pooled potentials into one matrix. Frequency-specific decomposition methods revealed cornucopia neural defined by coherent spatiotemporal time. reveal rich, dynamic, foraging behavior.