Infection with foot-and-mouth disease virus results in a rapid reduction of MHC class I surface expression.

摘要: The modulation of MHC class I molecule expression on the surface cells as a consequence foot-and-mouth disease virus (FMDV) infection has been examined. On infected with FMDV, was reduced to approximately 70% initial value 3 h after and 53% 6 h. depleted complexes by acid treatment, appearance newly assembled I-peptide cell non-infected increased immediately upon neutralization original levels were recovered in about 20 In contrast, new peptide-bound molecules inhibited early 30 min FMDV infection. Since shut-down FMDV-mediated host protein synthesis occurs 2-3 post-infection, this result suggests that an earlier event, which prevents synthesized complexes, is induced following Thus, FMDV-infected rapidly become unable present viral peptides association T lymphocytes. Such mechanism would assist evasion cytotoxic immune response host.