Basic Fibroblast Growth Factor Ameliorates Endothelial Dysfunction in Radiation-Induced Bladder Injury
作者： Shiwei Zhang , Xuefeng Qiu , Yanting Zhang , Kai Fu , Xiaozhi Zhao
DOI: 10.1155/2015/967680
关键词:
摘要: This study was designed to explore the effect of basic fibroblast growth factor (bFGF) on radiation-induced endothelial dysfunction and histological changes in urinary bladder. bFGF administrated human umbilical vein cells (HUVEC) or bladder immediately after radiation. Reduced expression thrombomodulin (TM) indicated HUVEC treatment with Decreased apoptosis observed treated bFGF. Administration increased TM medium, as well at early delayed phases injury (RIBI). At phase, injection thickness urothelium reduced inflammation within effective reducing fibrosis Our results indicate that is a prominent feature RIBI. can ameliorate preserve histology
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Junru Wang, Marjan Boerma, Qiang Fu, Martin HauerJensen, Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy World Journal of Gastroenterology. ,vol. 13, pp. 3047- 3055 ,(2007) , 10.3748/WJG.V13.I22.3047
Junru Wang, Huaien Zheng, Xuemei Ou, Louis M. Fink, Martin Hauer-Jensen, Deficiency of Microvascular Thrombomodulin and Up-Regulation of Protease-Activated Receptor-1 in Irradiated Rat Intestine The American Journal of Pathology. ,vol. 160, pp. 2063- 2072 ,(2002) , 10.1016/S0002-9440(10)61156-X
Douglas B. Cines, Rodger P. McEver, Joseph Loscalzo, Jordan S. Pober, Guy A. Zimmerman, Eleanor S. Pollak, Ann Marie Schmidt, Keith R. McCrae, David M. Stern, Barbara A. Konkle, Elliot S. Barnathan, Bradford S. Schwartz, Timothy M. Wick, Clayton A. Buck, Bruce A. Hug, Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders Blood. ,vol. 91, pp. 3527- 3561 ,(1998) , 10.1182/BLOOD.V91.10.3527
Naoshi Kinoshita, Masayoshi Tsuda, Rodrigo Hamuy, Masahiro Nakashima, Tomomi Nakamura-Kurashige, Mutsumi Matsuu-Matsuyama, Akiyoshi Hirano, Sadanori Akita, The usefulness of basic fibroblast growth factor for radiation-exposed tissue Wound Repair and Regeneration. ,vol. 20, pp. 91- 102 ,(2012) , 10.1111/J.1524-475X.2011.00758.X
Stewart Fa, Mechanism of bladder damage and repair after treatment with radiation and cytostatic drugs. The British journal of cancer. Supplement. ,vol. 7, pp. 280- 291 ,(1986)
Adriana Haimovitz-Friedman, Carlos Cordon-Cardo, Alan Alfieri, Maureen McLoughlin, Zvi Fuks, Desiree Ehleiter, Jeffery L. Schwartz, Andrew P. Seddon, Roger S. Persaud, Basic Fibroblast Growth Factor Protects Endothelial Cells against Radiation-induced Programmed Cell Death in Vitro and in Vivo Cancer Research. ,vol. 54, pp. 2582- 2590 ,(1994)
Lurong Zhang, Weimin Sun, Jianjun Wang, Mei Zhang, Shanmin Yang, Yeping Tian, Sadasivan Vidyasagar, Louis A. Peña, Kunzhong Zhang, Yongbing Cao, Liangjie Yin, Wei Wang, Lei Zhang, Katherine L. Schaefer, Lawrence J. Saubermann, Steven G. Swarts, Bruce M. Fenton, Peter C. Keng, Paul Okunieff, Mitigation effect of an FGF-2 peptide on acute gastrointestinal syndrome after high-dose ionizing radiation. International Journal of Radiation Oncology Biology Physics. ,vol. 77, pp. 261- 268 ,(2010) , 10.1016/J.IJROBP.2009.11.026
J Jaal, W Dörr, Early and long-term effects of radiation on intercellular adhesion molecule 1 (ICAM-1) expression in mouse urinary bladder endothelium. International Journal of Radiation Biology. ,vol. 81, pp. 387- 395 ,(2005) , 10.1080/09553000500147600
Jana Jaal, Wolfgang Dörr, Effect of Recombinant Human Keratinocyte Growth Factor (rHuKGF, Palifermin) on Radiation-Induced Mouse Urinary Bladder Dysfunction International Journal of Radiation Oncology*Biology*Physics. ,vol. 69, pp. 528- 533 ,(2007) , 10.1016/J.IJROBP.2007.05.074
D. G. Kirsch, P. M. Santiago, E. di Tomaso, J. M. Sullivan, W.-S. Hou, T. Dayton, L. B. Jeffords, P. Sodha, K. L. Mercer, R. Cohen, O. Takeuchi, S. J. Korsmeyer, R. T. Bronson, C. F. Kim, K. M. Haigis, R. K. Jain, T. Jacks, p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis Science. ,vol. 327, pp. 593- 596 ,(2010) , 10.1126/SCIENCE.1166202