Immunological Adverse Effects of Anticonvulsants. What Is Their Clinical Relevance

摘要: Long term administration of anticonvulsants is sometimes associated with impairment the humoral and/or cellular immune response. Furthermore, certain well known adverse reactions to antiepileptics may have an immunotoxicological origin e.g. lymphadenopathy, pseudolymphoma and systemic lupus erythematosus. However, two important questions remain unresolved. First, possibility that epilepsy per se might be primarily alterations makes it difficult assess pathogenetic role a specific drug, especially in patient population usually on multiple drug therapy. Secondly, clinical relevance some observed immunological abnormalities still highly controversial.