Examining the evidence on the causal effect of HAART on transmission of HIV using the Bradford Hill criteria.

摘要: In recent years, evidence has accumulated regarding the ability of HAART to prevent HIV transmission. Early supportive was derived from observational, ecological and population-based studies. More recently, a randomized clinical trial showed that immediate use led 96% decrease in transmission events within serodiscordant heterosexual couples. However, generalizability effect HAART, population-level impact on continues generate substantial debate. We, therefore, conducted review preventive context Bradford Hill criteria for causality. Taken together, we find supporting treatment as prevention meets each We conclude opportunity cost inaction while waiting additional other risk groups is too high. Efforts should be redoubled mobilize financial capital political will optimize implementation Treatment Prevention strategies wide scale.