Nerve allograft transplantation: a review.

摘要: Peripheral nerves that are interrupted by trauma or surgical resection require reapproximation of their ends. When primary repair cannot be performed without undue tension, nerve grafting is required. Nerve with autograft limited when there insufficient amount autologous available for large defects. This encouraged the search alternative means reconstruction in extensive injuries. The cadaveric allograft provides an unlimited graft source morbidities associated reconstruction; but these grafts rapidly rejected unless appropriate recipient immunosuppression achieved. An optimal treatment method transplantation must minimize prevent rejection while permitting regeneration at same time. In this report, literature experimental studies, strategies to rejection, and reported clinical experiences reviewed.