Correlative analysis of plasma SN-38 levels and DPD activity with outcomes of FOLFIRI regimen for metastatic colorectal cancer with UGT1A1 *28 and *6 wild type and its implication for individualized chemotherapy.

摘要: ABSTRACTIt remains uncertain whether there is an correlation between clinical pharmacokinetic parameters and outcomes for metastatic colorectal cancer especially with UGT1A1 *28 *6 wild type (*1/*1-*1/*1) serious events associated Irinotecan are largely excluded. This study retrospectively analyzed the relationship metabolite levels of *1/*1-*1/*1 genotype arrangement. Blood samples (n = 244) were collected analysis plasma DPD activity (before first chemotherapy) SN-38 (1.5 49 hour after CPT-11 administration). Clinical variables such as toxicity then assessed. Of *1/*1 -*1/*1 combination, median progression free survival CSN-38 1.5 h > 50.24 ng/ml subset was remarkably longer than that ≤ subset. However, no differences 49 h 15.25 ng/ml subgroup group. It lower responsible rela...