Non-Cell-Autonomous Regulation of Optic Nerve Regeneration by Amacrine Cells.

摘要: Visual information is conveyed from the eye to brain through axons of retinal ganglion cells (RGCs) that course optic nerve and synapse onto neurons in multiple subcortical visual relay areas. RGCs cannot regenerate their once they are damaged, similar most mature central nervous system (CNS), soon undergo cell death. These phenomena neurodegeneration regenerative failure widely viewed as being determined by cell-intrinsic mechanisms within or be influenced extracellular environment, including glial inflammatory cells. However, a new concept emerging death survival ability also complex circuitry retina activation multicellular signaling cascade involving changes inhibitory interneurons - amacrine (AC) contributes fate RGCs. Here, we review our current understanding role play axon regeneration after injury.