Bruton's tyrosine kinase inhibitors for the treatment of rheumatoid arthritis
作者： Jennifer A. Whang , Betty Y. Chang
DOI: 10.1016/J.DRUDIS.2014.03.028
关键词:
摘要: The function and role of Bruton's tyrosine kinase (BTK) in human B cell development was demonstrated by its association with X-linked agammaglobulinemia (XLA) manifested a substantial reduction immunoglobulins cells. BTK has crucial pre-B receptor (BCR) BCR signaling during normal activation. Aberrant is associated autoimmune diseases, such as rheumatoid arthritis (RA). In addition, also expressed myeloid populations, including monocytes, macrophages, neutrophils mast These innate cells infiltrate the synovial cavity produce inflammatory cytokines, aggravating arthritic symptoms. functions downstream Fcγ receptors (FcγR) Fcɛ (FcɛR). absence BTK, FcR-mediated functions, cytokine production, are impaired. Xid mice, which have mutation decreased susceptibility to developing collagen-induced (CIA). Given that involved multiple pathways FcR, it an attractive therapeutic target for RA.
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sci-hub.se 参考文章(39)
Jenny Jongstra-Bilen, Adrianet Puig Cano, Manvi Hasija, Haiyan Xiao, C. I. Edvard Smith, Myron I. Cybulsky, Dual Functions of Bruton’s Tyrosine Kinase and Tec Kinase during Fcγ Receptor-Induced Signaling and Phagocytosis Journal of Immunology. ,vol. 181, pp. 288- 298 ,(2008) , 10.4049/JIMMUNOL.181.1.288
Toshiyuki Takai, Roles of Fc receptors in autoimmunity Nature Reviews Immunology. ,vol. 2, pp. 580- 592 ,(2002) , 10.1038/NRI856
Sandra Kleinau, Birgitta Heyman, Pernilla Martinsson, Susanne Gustavsson, Importance of CD23 for collagen-induced arthritis: delayed onset and reduced severity in CD23-deficient mice. Journal of Immunology. ,vol. 162, pp. 4266- 4270 ,(1999)
L. JANSSON, R. HOLMDAHL, Genes on the X chromosome affect development of collagen‐induced arthritis in mice Clinical and Experimental Immunology. ,vol. 94, pp. 459- 465 ,(2008) , 10.1111/J.1365-2249.1993.TB08218.X
J. C. W. Edwards, G. Cambridge, Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes Rheumatology. ,vol. 40, pp. 205- 211 ,(2001) , 10.1093/RHEUMATOLOGY/40.2.205
Wasif N Khan, Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase. Immunologic Research. ,vol. 23, pp. 147- 156 ,(2001) , 10.1385/IR:23:2-3:147
Anne B Satterthwaite, Zuomei Li, Owen N Witte, Btk function in B cell development and response Seminars in Immunology. ,vol. 10, pp. 309- 316 ,(1998) , 10.1006/SMIM.1998.0123
James D. Kerner, Mark W. Appleby, Randolph N. Mohr, Sylvia Chien, David J. Rawlings, Charles R. Maliszewski, Owen N. Witte, Roger M. Perlmutte, Impaired expansion of mouse B cell progenitors lacking Btk Immunity. ,vol. 3, pp. 301- 312 ,(1995) , 10.1016/1074-7613(95)90115-9
Zhengying Pan, Heleen Scheerens, Shyr-Jiann Li, Brian E Schultz, Paul A Sprengeler, L Chuck Burrill, Rohan V Mendonca, Michael D Sweeney, Keana CK Scott, Paul G Grothaus, Douglas A Jeffery, Jill M Spoerke, Lee A Honigberg, Peter R Young, Stacie A Dalrymple, James T Palmer, None, Discovery of Selective Irreversible Inhibitors for Bruton’s Tyrosine Kinase ChemMedChem. ,vol. 2, pp. 58- 61 ,(2007) , 10.1002/CMDC.200600221
Laurens P. Kil, Marjolein J. W. de Bruijn, Menno van Nimwegen, Odilia B. J. Corneth, Jan Piet van Hamburg, Gemma M. Dingjan, Friedrich Thaiss, Guus F. Rimmelzwaan, Dirk Elewaut, Dianne Delsing, Pieter Fokko van Loo, Rudi W. Hendriks, Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice Blood. ,vol. 119, pp. 3744- 3756 ,(2012) , 10.1182/BLOOD-2011-12-397919