The biological paths of IL‐1 family members IL‐18 and IL‐33
作者： Dirk E. Smith
DOI: 10.1189/JLB.0810470
关键词:
摘要: Cytokines are key mediators of the immune system, and few have been more thoroughly studied than those IL-1 family. IL-1α IL-1β founding members now celebrate 25 years since their cloning. In that time, IL-1-directed research has illuminated many aspects cytokine biology innate immunity. The family is recognized to include 11 total members, including IL-18 IL-33, which topic this review. These two inflammatory cytokines expressed broadly, actions influence a variety physiologic responses involved in inflammation purpose article not provide an exhaustive review IL-33 but rather, summarize what known about functions perspective on similarities differences.
jleukbio.org参考文章(170)
Maho Suzukawa, Motoyasu Iikura, Rikiya Koketsu, Hiroyuki Nagase, Chise Tamura, Akiko Komiya, Susumu Nakae, Kouji Matsushima, Ken Ohta, Kazuhiko Yamamoto, Masao Yamaguchi, An IL-1 Cytokine Member, IL-33, Induces Human Basophil Activation via Its ST2 Receptor Journal of Immunology. ,vol. 181, pp. 5981- 5989 ,(2008) , 10.4049/JIMMUNOL.181.9.5981
Errol P. Prens, Robert Benner, Vicent H.J. van der Velden, Arjen R. Companjen, Reno Debets, André Vooys, Human keratinocytes are major producers of IL-18: predominant expression of the unprocessed form. European Cytokine Network. ,vol. 11, pp. 383- 390 ,(2000)
Katarzyna Bulek, Shadi Swaidani, Jinzhong Qin, Yi Lu, Muhammet F. Gulen, Tomasz Herjan, Booki Min, Robert A. Kastelein, Mark Aronica, Magdalena Kosz-Vnenchak, Xiaoxia Li, The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response. Journal of Immunology. ,vol. 182, pp. 2601- 2609 ,(2009) , 10.4049/JIMMUNOL.0802729
Tatjana Eigenbrod, Jong-Hwan Park, Jürgen Harder, Yoichiro Iwakura, Gabriel Núñez, Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1α Released from Dying Cells Journal of Immunology. ,vol. 181, pp. 8194- 8198 ,(2008) , 10.4049/JIMMUNOL.181.12.8194
Tomohiro Yoshimoto, Hitoshi Mizutani, Hiroko Tsutsui, Nancy Noben-Trauth, Kei-ichi Yamanaka, Minoru Tanaka, Shinzo Izumi, Haruki Okamura, William E. Paul, Kenji Nakanishi, IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6. Nature Immunology. ,vol. 1, pp. 132- 137 ,(2000) , 10.1038/77811
Alexey G. Murzin, Arthur M. Lesk, Cyrus Chothia, β-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1β and 1α and fibroblast growth factors Journal of Molecular Biology. ,vol. 223, pp. 531- 543 ,(1992) , 10.1016/0022-2836(92)90668-A
M.B. Kalousek, T. Trüb, M. Schuermann, R. Klemenz, T1 is a c-Fos- and FosB-responsive gene which is induced by growth factors through multiple signal transduction pathways. Journal of Biological Chemistry. ,vol. 269, pp. 6866- 6873 ,(1994) , 10.1016/S0021-9258(17)37455-0
Maria C. Leite-de-Moraes, Agathe Hameg, Maria Pacilio, Yasuhiko Koezuka, Masaru Taniguchi, Luc Van Kaer, Elke Schneider, Michel Dy, André Herbelin, IL-18 Enhances IL-4 Production by Ligand-Activated NKT Lymphocytes: A Pro-Th2 Effect of IL-18 Exerted Through NKT Cells The Journal of Immunology. ,vol. 166, pp. 945- 951 ,(2001) , 10.4049/JIMMUNOL.166.2.945
Teresa L. Born, Lynda A. Morrison, David J. Esteban, Tim VandenBos, Lydia G. Thebeau, Nanhai Chen, Melanie K. Spriggs, John E. Sims, R. Mark L. Buller, A Poxvirus Protein That Binds to and Inactivates IL-18, and Inhibits NK Cell Response The Journal of Immunology. ,vol. 164, pp. 3246- 3254 ,(2000) , 10.4049/JIMMUNOL.164.6.3246
David Préfontaine, Stéphane Lajoie-Kadoch, Susan Foley, Séverine Audusseau, Ron Olivenstein, Andrew J. Halayko, Catherine Lemière, James G. Martin, Qutayba Hamid, Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells Journal of Immunology. ,vol. 183, pp. 5094- 5103 ,(2009) , 10.4049/JIMMUNOL.0802387