VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2/B1 and osteopontin.
作者： Michelle J. Nyhan , Gerald C. O’Sullivan , Tracey R. O’Donovan , Paul Sweeney , Sharon L. McKenna
DOI: 10.3233/ACP-CLO-2010-0541
关键词:
摘要: Background Von Hippel-Lindau (VHL) tumour suppressor gene inactivation is associated with clear cell renal carcinoma (CCRCC) development. The VHL protein (pVHL) has been proposed to regulate the expression of several proteins including Hypoxia Inducible Factor-α (HIF-α), carbonic anhydrase (CA)IX, heterogeneous nuclear ribonucleoprotein (hnRNP)A2/B1 and osteopontin. pVHL characterized in vitro, however, clinical studies are limited. We evaluated impact genetic alterations on targets paired normal tumor tissue.
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