The possible role of the arterial microcirculation in the pathogenesis of atherosclerosis

摘要: Abstract Figure 3 outlines the microvascular hypothesis of atherosclerosis. We propose that arterial microcirculation contributes to atherosclerosis through at least three mechanisms. First, injury arterioles or arteriolar capillaries might cause increased passage lipoproteins into subintimal tissue (Fig. 3A). This process could continue even when a large fibrous cap prevents transintimal filtration. Second, in areas where vasa vasorum (primary vascularization) are sparse lacking, removal lipids and be retarded enhancing their accumulation 3B). Third, defective secondary vascularization existing plaques an additional source for wall 3C). Thus, we investigators should take fresh look role as factor pathogenesis