Patterns of remission in pemphigus vulgaris

摘要: Abstract Background: The incidence of remissions in pemphigus is unclear because these are usually reported at a single point the evolution disease. Thus it uncertain whether treatment simply suppresses manifestations disease and consequently must be continuously administered, or induces complete long-lasting that permit therapy to discontinued. Objective: To answer this question, we investigated remission long-term longitudinal study. Methods: induction (lesion free with no systemic for least 6 months) was studied 40 patients vulgaris treated conventionally followed up an average 7.7 years by same investigator. Results: Five (5%) died Complete were induced 25%, 50%, 75% 2, 5, 10 years, respectively, after diagnosis. Most remaining partial had mild controlled small dose steroids. course different patterns, some rapidly entering remissions, whereas others never entered into remission. related initial severity extent early response treatment. Conclusion: It possible eventually induce durable most safely discontinued without flare activity. proportion whom can achieved increases steadily time, approximately years. (J Am Acad Dermatol 2000;42:422-7.)