Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR.

摘要: A large body of evidence indicates that metazoan innate immunity is regulated by the nervous system, but mechanisms involved in process and biological importance such control remain unclear. We show a neural circuit involving npr-1, which encodes G protein-coupled receptor (GPCR) related to mammalian neuropeptide Y receptors, functions suppress immune responses. The inhibitory function requires guanosine 3',5'-monophosphate-gated ion channel encoded tax-2 tax-4 as well soluble guanylate cyclase GCY-35. Furthermore, we npr-1- gcy-35-expressing sensory neurons actively responses nonneuronal tissues. full-genome microarray analysis on animals with altered due mutation npr-1 shows an enrichment genes are markers responses, including those conserved PMK-1/p38 mitogen-activated protein kinase signaling pathway. These results present directly C. elegans, suggesting GPCRs may participate circuits receive inputs from either pathogens or infected sites integrate them coordinate appropriate