Genetic Association Analysis of Cell Cycle Regulators Reveals YWHAZ Has Prognostic Significance in Prostate Cancer.
作者： CHIA-CHENG YU , LIH-CHYANG CHEN , WEN-HSIN LIN , VICTOR C. LIN , CHAO-YUAN HUANG
DOI: 10.21873/CGP.20181
关键词:
摘要: Background/aim This study aimed to identify the genes that cause biochemical recurrence (BCR) following radical prostatectomy (RP) in men with localized prostate cancer. Patients and methods A two-stage genetic association of 19 single-nucleotide polymorphisms 11 key cell cycle regulation was carried out. BCR-free survival after RP evaluated a discovery cohort 458 patients cancer, replication investigated another 185 patients. Results consistent found between BCR rs2290291 (discovery: p=0.008; replication: p=0.029). is located tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), predicted possess regulatory function affected YWHAZ expression. Furthermore, expression frequently up-regulated advanced tumours, associated poorer Conclusion be BCR. may as putative oncogene during cancer progression.
sci-hub.se 参考文章(31)
C.-N. Huang, S.-P. Huang, J.-B. Pao, T.-C. Hour, T.-Y. Chang, Y.-H. Lan, T.-L. Lu, H.-Z. Lee, S.-H. Juang, P.-P. Wu, C.-Y. Huang, C.-J. Hsieh, B.-Y. Bao, Genetic polymorphisms in oestrogen receptor-binding sites affect clinical outcomes in patients with prostate cancer receiving androgen-deprivation therapy. Journal of Internal Medicine. ,vol. 271, pp. 499- 509 ,(2012) , 10.1111/J.1365-2796.2011.02449.X
Shu-Pin Huang, Eric Lévesque, Chantal Guillemette, Chia-Cheng Yu, Chao-Yuan Huang, Victor C. Lin, I-Che Chung, Lih-Chyang Chen, Isabelle Laverdière, Louis Lacombe, Yves Fradet, Ta-Yuan Chang, Hong-Zin Lee, Shin-Hun Juang, Bo-Ying Bao, Genetic variants in microRNAs and microRNA target sites predict biochemical recurrence after radical prostatectomy in localized prostate cancer. International Journal of Cancer. ,vol. 135, pp. 2661- 2667 ,(2014) , 10.1002/IJC.28904
Roopika Menon, Mario Deng, Kerstin Rüenauver, Angela Queisser, Martin Pfeifer, Anne Offermann, Diana Boehm, Wenzel Vogel, Veit Scheble, Falko Fend, Glen Kristiansen, Nicolas Wernert, Nicole Oberbeckmann, Saskia Biskup, Mark A Rubin, Zaki Shaikhibrahim, Sven Perner, Somatic copy number alterations by whole-exome sequencing implicates YWHAZ and PTK2 in castration-resistant prostate cancer. The Journal of Pathology. ,vol. 231, pp. 505- 516 ,(2013) , 10.1002/PATH.4274
Wm. David Henner, Adam J. Evans, Kristi M. Hough, Emily L. Harris, Bruce A. Lowe, Tomasz M. Beer, Association of codon 72 polymorphism of p53 with lower prostate cancer risk. The Prostate. ,vol. 49, pp. 263- 266 ,(2001) , 10.1002/PROS.10021
H Fu, K Xia, D. Pallas, C Cui, K Conroy, R. Narsimhan, H Mamon, R. Collier, T. Roberts, Interaction of the protein kinase Raf-1 with 14-3-3 proteins Science. ,vol. 266, pp. 126- 129 ,(1994) , 10.1126/SCIENCE.7939632
Gavin W. Porter, Fadlo R. Khuri, Haian Fu, Dynamic 14-3-3/client protein interactions integrate survival and apoptotic pathways. Seminars in Cancer Biology. ,vol. 16, pp. 193- 202 ,(2006) , 10.1016/J.SEMCANCER.2006.03.003
Lizhong Wang, Tomonori Habuchi, Kenji Mitsumori, Zhenhua Li, Toshiyuki Kamoto, Hidefumi Kinoshita, Norihiko Tsuchiya, Kazunari Sato, Chikara Ohyama, Akira Nakamura, Osamu Ogawa, Tetsuro Kato, Increased risk of prostate cancer associated with AA genotype of cyclin D1 gene A870G polymorphism. International Journal of Cancer. ,vol. 103, pp. 116- 120 ,(2003) , 10.1002/IJC.10793
John Lonsdale, Jeffrey Thomas, Mike Salvatore, Rebecca Phillips, Edmund Lo, Saboor Shad, Richard Hasz, Gary Walters, Fernando Garcia, Nancy Young, Barbara Foster, Mike Moser, Ellen Karasik, Bryan Gillard, Kimberley Ramsey, Susan Sullivan, Jason Bridge, Harold Magazine, John Syron, Johnelle Fleming, Laura Siminoff, Heather Traino, Maghboeba Mosavel, Laura Barker, Scott Jewell, Dan Rohrer, Dan Maxim, Dana Filkins, Philip Harbach, Eddie Cortadillo, Bree Berghuis, Lisa Turner, Eric Hudson, Kristin Feenstra, Leslie Sobin, James Robb, Phillip Branton, Greg Korzeniewski, Charles Shive, David Tabor, Liqun Qi, Kevin Groch, Sreenath Nampally, Steve Buia, Angela Zimmerman, Anna Smith, Robin Burges, Karna Robinson, Kim Valentino, Deborah Bradbury, Mark Cosentino, Norma Diaz-Mayoral, Mary Kennedy, Theresa Engel, Penelope Williams, Kenyon Erickson, Kristin Ardlie, Wendy Winckler, Gad Getz, David DeLuca, Daniel MacArthur, Manolis Kellis, Alexander Thomson, Taylor Young, Ellen Gelfand, Molly Donovan, Yan Meng, George Grant, Deborah Mash, Yvonne Marcus, Margaret Basile, Jun Liu, Jun Zhu, Zhidong Tu, Nancy J Cox, Dan L Nicolae, Eric R Gamazon, Hae Kyung Im, Anuar Konkashbaev, Jonathan Pritchard, Matthew Stevens, Timothèe Flutre, Xiaoquan Wen, Emmanouil T Dermitzakis, Tuuli Lappalainen, Roderic Guigo, Jean Monlong, Michael Sammeth, Daphne Koller, Alexis Battle, Sara Mostafavi, Mark McCarthy, Manual Rivas, Julian Maller, Ivan Rusyn, Andrew Nobel, Fred Wright, Andrey Shabalin, Mike Feolo, Nataliya Sharopova, Anne Sturcke, Justin Paschal, James M Anderson, Elizabeth L Wilder, Leslie K Derr, Eric D Green, Jeffery P Struewing, Gary Temple, Simona Volpi, Joy T Boyer, Elizabeth J Thomson, Mark S Guyer, Cathy Ng, Assya Abdallah, Deborah Colantuoni, Thomas R Insel, Susan E Koester, A Roger Little, Patrick K Bender, Thomas Lehner, Yin Yao, Carolyn C Compton, Jimmie B Vaught, Sherilyn Sawyer, Nicole C Lockhart, Joanne Demchok, Helen F Moore, The Genotype-Tissue Expression (GTEx) project Nature Genetics. ,vol. 45, pp. 580- 585 ,(2013) , 10.1038/NG.2653
Adam S. Kibel, Carol H. Jin, Aleksandra Klim, Jason Luly, Kimberly A. Roehl, William S. Wu, Brian K. Suarez, Association between polymorphisms in cell cycle genes and advanced prostate carcinoma The Prostate. ,vol. 68, pp. 1179- 1186 ,(2008) , 10.1002/PROS.20784
, Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature. ,vol. 455, pp. 1061- 1068 ,(2008) , 10.1038/NATURE07385