The Effects of 1 mA tACS and tRNS on Children/Adolescents and Adults: Investigating Age and Sensitivity to Sham Stimulation.

摘要: The aim of this study was to investigate the effect transcranial random noise (tRNS) and alternating current (tACS) stimulation on motor cortex excitability in healthy children adolescents. Additionally, based our recent results individual response sham adults, we explored pediatric population. We included 15 adolescents (10-16 years) 28 adults (20-30 years). Participants were stimulated four times with 20 Hz 140 tACS, tRNS, (1 mA) for 10 minutes over left M1HAND. Single-pulse MEPs (motor evoked potential), short-interval intracortical inhibition, facilitation measured by TMS before after (baseline, 0, 30, 60 minutes). also investigated aspects tolerability. According immediately compared baseline (Wilcoxon signed-rank test), subjects regarded as responders or nonresponders sham. did not find a significant age effect. Regardless age, tACS led increased excitability. Incidence intensity side effects differ between groups type stimulation. Analyses showed Hz, tRNS single-pulse only nonresponders. In study, responded 1 mA comparably regarding modulation This contributes findings that noninvasive brain is well tolerated including which has been studied before. Finally, supports modulating role sensitivity responsiveness broader range.