Mutagenicity of diesel engine exhaust in the Ames / Salmonella assay using a direct exposure method
作者： Mamadou Fall , Hasnaà Haddouk , Stéphane Loriot , Amadou Diouf , Frédéric Dionnet
DOI: 10.1080/02772248.2011.619538
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摘要: The aim of this study was to investigate the potential mutagenic activity diesel engine exhaust in Ames/Salmonella assay using a direct aerosol exposure system. So, TA 98 and 100 strains, with or without added S9 mix, were exposed emissions after varying degrees filtration. Variants these two deficient nitroreductase (TA 98NR 100NR) over-expressing O-Acetyl Transferase (YG 1024 YG 1029), also total (unfiltered) highlight putative mutagenicity any nitro-PAHs present emissions. Mutagenic demonstrated on Salmonella typhimurium, strains variants NR YG1029. use particle filter did not modify genotoxicity emissions, indicating major contribution gas phase prominent role particulate-associated nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) claimed by some aut...
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