DNA polymerase: Correlation with DNA replication during transformation of human lymphocytes
作者： L.A. Loeb , S.S. Agarwal
DOI: 10.1016/0014-4827(71)90681-1
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摘要: Abstract The relationship between DNA polymerase activity and replication during lymphocyte transformation has been studied. On the same sample of cells, both thymidine incorporation were determined. induction precedes initiation replication; thereafter, activities increase proportionately over a 30-fold range. deoxynucleotide composition synthesized in vitro by homogenates stimulated lymphocytes is similar to that added template. accuracy dAT copolymer such equal amounts dATP dTTP are incorporated, while if any dCTP or dGTP incorporated it occurs at frequency less than 1 103.
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