Biological Activity and Mechanisms of Action of Somatocrinin, Growth Hormone Releasing Factor, on the Release of Growth Hormone in Vitro and its Antagonism by Somatostatin
作者： P. Brazeau , N. Ling , P. Böhlen , F. Esch , S. Y. Ying
DOI: 10.1007/978-3-642-61749-2_6
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摘要: The concept of a neurohumoral hypothalamic control the adenohypophysis as originally formulated by G. W. Harris was later expanded to propose that there would be one substance (a releasing factor, they were called later) involved for controlling secretion each pituitary hormone. ultimately validated with isolation and characterization in 1969 TRF, thyrotropin known now also release prolactin, 1971 LRF, luteinizing hormone follicle stimulating Regarding growth hormone, it has been since early 1960’s lesions will inhibit body along secretion, 1964 Durben Meites reported presence factor extracts tissues. search on ever since, no satisfactory results, despite earlier claims contrary.
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