Morphine-induced activation of A10 dopamine neurons in the rat.
作者： Katia Gysling , Rex Y. Wang
DOI: 10.1016/0006-8993(83)90913-7
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摘要: Abstract The effects of intravenous administration morphine (MOR) on the spontaneous discharge rate dopamine (DA) neurons in ventral tegmental area (VTA or A10) and substantia nigra pars compacta (SNC A9) were compared. MOR (0.5–3.5 mg/kg) produced a marked increase firing both A10 A9 DA neurons. Naloxone (NAL) reversed effects. Acute transection medial forebrain bundle (MFB) did not interfere with observed either However, following chronic lesions MFB (6 days), no longer responsive to whereas cells still activated by MOR. Neither radiofrequency dorsal raphe nucleus (DNR) nor 5-HT 2 antagonist ketanserin affected stimulatory effect cells. Thus, it is confirmed that depend striatonigral feedback pathways. In contrast, appears MOR-induced activation does afferents from projections DRN, suggesting more direct action Microiontophoretic application enkephalin analogues significantly increased activity these iontophoretic NAL. On other hand, intravenously (0.5–1.5 iontophoretically administered markedly suppressed electrical non-DA found vicinity neurons, this was completely It proposed could be mediated indirectly
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