Mathematical models in the study of drug kinetics
作者： Giorgio Segre
DOI: 10.1007/978-3-642-93048-5_12
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摘要: The theory of compartments represents the mathematical basis study pharmacokinetics. application such a to problems drug kinetics, that is movements followed by in organism, isolated organs or apparatuses, began with paper Gehlen (1), those Teorell (2) and Beccari (3). After second world war was clearly stated applied its different derivations several Authors: Dost (14), Rescigno Segre (5), Atkins (6), Notari (7), Wagner (8), Jaquez (9), Gladtke (10). Symposia have been held on this topic (11,12) scientific journals published pharmacokinetics (J. Pharmacokinetics Biopharmaceutics, Clinical Pharmacokinetics), whereas high proportion papers which appear clinical pharmacology are dealing essentially health autorities countries require detailed analysis for accepting new most leading companies developed laboratories
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