Increase in immune activation, vascular endothelial growth factor and erythropoietin after an ultramarathon run at moderate altitude.

摘要: Abstract The present study was performed to investigate the effects of exhaustive long lasting exercise at moderate altitude on time course serum immunomodulatory peptides, vascular endothelial growth factor (VEGF) and erythropoietin (EPO). Thirteen well trained runners participated Swiss Alpine Marathon Davos (distance 67 km, difference 2300 m). Interleukin-6 significantly elevated in first 2h after run. In contrast, tumor necrosis factor-α both soluble factor-a receptors I II were increased termination showed sustained concentrations following days. Neopterin, a marker for activation cellular immune system, until day two Immediately run VEGF further 2.4-fold five post (p = 0.005). EPO also but reached its maximum 2 h (2-fold increase; p 0.004) decreased thereafter. main findings our are that prolonged strenuous induced significant increase which accompanied by an system.