Use of Biomarkers for the Prediction of Treatment Response: Immunoadsorption in Dilated Cardiomyopathy as a Clinical Example

摘要: In this chapter, we outline a clinical example illustrating how integrated analyses of biomarkers might be used for the prediction treatment response. We report findings from pilot study that investigated hemodynamic effects novel option, immunoadsorption with subsequent IgG substitution (IA/IgG), in patients dilated cardiomyopathy. Several previous studies have shown leads to significant improvement cardiac function and relief symptoms. Response therapy is, however, characterized by wide inter-individual variability. study, tested value clinical, biochemical molecular parameters response IA/IgG. This demonstrated combined assessment two markers (negative inotropic activity antibodies blood gene expression patterns derived myocardial biopsies) predicts an extremely high sensitivity specificity, thereby enabling appropriate selection who most likely benefit therapeutic intervention. Further will screen biomarker signatures blood, which do not depend on endomyocardial biopsies, compare responders non-responders respect other (e.g. plasma proteome, metabolome microRNA profiles as well whole transcriptome signatures). future, such strategies facilitate cardiomyopathy are only but also heart failure treatments heterogeneous is observed thus help offer more effective affected patients.