Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection
作者： Katherine V. Houser , Lisa Gretebeck , Tianlei Ying , Yanping Wang , Leatrice Vogel
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摘要: With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent limit the disease. We examined in vivo efficacy monoclonal antibody m336, which has high neutralizing activity against MERS-CoV vitro. m336 was administered rabbits intravenously or intranasally before infection MERS-CoV. Prophylaxis resulted reduction pulmonary viral RNA titers by 40-9000-fold, compared an irrelevant control little no inflammation antigen detected. This protection supports further clinical development m336.
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Neeltje van Doremalen, Vincent J. Munster, Animal models of Middle East respiratory syndrome coronavirus infection. Antiviral Research. ,vol. 122, pp. 28- 38 ,(2015) , 10.1016/J.ANTIVIRAL.2015.07.005
Victor H. Leyva-Grado, Gene S. Tan, Paul E. Leon, Mark Yondola, Peter Palese, Direct Administration in the Respiratory Tract Improves Efficacy of Broadly Neutralizing Anti-Influenza Virus Monoclonal Antibodies Antimicrobial Agents and Chemotherapy. ,vol. 59, pp. 4162- 4172 ,(2015) , 10.1128/AAC.00290-15
Kristen E. Pascal, Christopher M. Coleman, Alejandro O. Mujica, Vishal Kamat, Ashok Badithe, Jeanette Fairhurst, Charleen Hunt, John Strein, Alexander Berrebi, Jeanne M. Sisk, Krystal L. Matthews, Robert Babb, Gang Chen, Ka-Man V. Lai, Tammy T. Huang, William Olson, George D. Yancopoulos, Neil Stahl, Matthew B. Frieman, Christos A. Kyratsous, Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Proceedings of the National Academy of Sciences of the United States of America. ,vol. 112, pp. 8738- 8743 ,(2015) , 10.1073/PNAS.1510830112
Mustafa Saad Mustafa Saad, AS Omrani, Kamran Baig Kamran Baig, Abdelkarim Bahloul Abdelkarim Bahloul, Fatehi Elzein Fatehi Elzein, MA Matin, MAA Selim, M Al-Mutairi, D Al-Nakhli, AY Al-Aidaroos, N Al-Sherbeeni, HI Al-Khashan, ZA Memish, AM Albarrak, None, Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia International Journal of Infectious Diseases. ,vol. 29, pp. 301- 306 ,(2014) , 10.1016/J.IJID.2014.09.003
Wayne A Marasco, Jianhua Sui, The growth and potential of human antiviral monoclonal antibody therapeutics Nature Biotechnology. ,vol. 25, pp. 1421- 1434 ,(2007) , 10.1038/NBT1363
Abdullah Assiri, Jaffar A Al-Tawfiq, Abdullah A Al-Rabeeah, Fahad A Al-Rabiah, Sami Al-Hajjar, Ali Al-Barrak, Hesham Flemban, Wafa N Al-Nassir, Hanan H Balkhy, Rafat F Al-Hakeem, Hatem Q Makhdoom, Alimuddin I Zumla, Ziad A Memish, Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Lancet Infectious Diseases. ,vol. 13, pp. 752- 761 ,(2013) , 10.1016/S1473-3099(13)70204-4
Bart L. Haagmans, Judith M.A. van den Brand, Lisette B. Provacia, V. Stalin Raj, Koert J. Stittelaar, Sarah Getu, Leon de Waal, Theo M. Bestebroer, Geert van Amerongen, Georges M.G.M. Verjans, Ron A.M. Fouchier, Saskia L. Smits, Thijs Kuiken, and, Albert D.M.E. Osterhaus, Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits Journal of Virology. ,vol. 89, pp. 6131- 6135 ,(2015) , 10.1128/JVI.00661-15
Mohammad Mousa Al-Abdallat, Daniel C. Payne, Sultan Alqasrawi, Brian Rha, Rania A. Tohme, Glen R. Abedi, Mohannad Al Nsour, Ibrahim Iblan, Najwa Jarour, Noha H. Farag, Aktham Haddadin, Tarek Al-Sanouri, Azaibi Tamin, Jennifer L. Harcourt, David T. Kuhar, David L. Swerdlow, Dean D. Erdman, Mark A. Pallansch, Lia M. Haynes, Susan I. Gerber, Nabil Sabri, Mohammad Al Azhari, Hala Khazali, Mohammad Al Maayah, Adel Bilbeisi, Naim Dawood, Bilal Al Zubi, Jawad Meflih, Tony Mounds, Julia Fitzner, Akram Eltom, Ali Mafi, Congrong Miao, Hayat Caidi, Suvang Trivedi, Shifaq Kamili, Aron J. Hall, Aaron Curns, Jessica Moore, Huong Pham, Chris Zimmerman, Eileen Farnon, Genessa Giorgi, Russell Gerber, Hospital-Associated Outbreak of Middle East Respiratory Syndrome Coronavirus: A Serologic, Epidemiologic, and Clinical Description Clinical Infectious Diseases. ,vol. 59, pp. 1225- 1233 ,(2014) , 10.1093/CID/CIU359
Candy C. Y. Lau, Lu Lu, Qi Liu, Lili Wang, Yang Feng, Yanping Wang, Bo-Jian Zheng, Kwok-Yung Yuen, Shibo Jiang, Dimiter S. Dimitrov, Tianlei Ying, Lanying Du, Tina W. Ju, Ponraj Prabakaran, Exceptionally Potent Neutralization of Middle East Respiratory Syndrome Coronavirus by Human Monoclonal Antibodies Journal of Virology. ,vol. 88, pp. 7796- 7805 ,(2014) , 10.1128/JVI.00912-14
Abdullah Assiri, Allison McGeer, Trish M. Perl, Connie S. Price, Abdullah A. Al Rabeeah, Derek A.T. Cummings, Zaki N. Alabdullatif, Maher Assad, Abdulmohsen Almulhim, Hatem Makhdoom, Hossam Madani, Rafat Alhakeem, Jaffar A. Al-Tawfiq, Matthew Cotten, Simon J. Watson, Paul Kellam, Alimuddin I. Zumla, Ziad A. Memish, Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus The New England Journal of Medicine. ,vol. 369, pp. 407- 416 ,(2013) , 10.1056/NEJMOA1306742