Restrictive allograft syndrome (RAS): A novel form of chronic lung allograft dysfunction

摘要: Background Bronchiolitis obliterans syndrome (BOS) with small-airway pathology and obstructive pulmonary physiology may not be the only form of chronic lung allograft dysfunction (CLAD) after transplantation. Characteristics a CLAD consisting restrictive functional changes involving peripheral were investigated. Methods Patients who received bilateral transplantation from 1996 to 2009 retrospectively analyzed. Baseline function was taken as time peak forced expiratory volume in 1 second (FEV ) . defined irreversible decline FEV Results Among 468 patients, developed 156; those, 47 (30%) showed RAS phenotype. Compared 109 BOS patients significant computed tomography findings interstitial disease ( p = 0.0003). The phenotype most risk factor death among other variables onset (hazard ratio, 1.60; confidential interval, 1.23–2.07). Conclusions is novel that exhibits characteristics fibrosis significantly affects survival transplant patients.