Effect of Paraoxonase 1 Polymorphisms on the Response of Lipids and Lipoprotein-associated Enzymes to Treatment with Fluvastatin

摘要: Background Decreased paraoxonase 1 (PON1) and increased total serum lipoprotein-associated phospholipase A 2 (Lp-PLA ) activities are suggested to be risk factors for vascular disease. Common PON1 genetic polymorphisms (Q192R L55M) significantly affect activity may also influence high-density lipoprotein (HDL)-associated Lp-PLA activity. However, little is known about the possible effect of common on response lipids as well treatment with statins. Methods Two hundred two hypercholesterolemic patients were treated fluvastatin 40 mg/day. Fasting lipids, Q192R L55M (total HDL-associated) determined before after 6 months treatment. Results Fluvastatin did not HDL-cholesterol or apolipoprotein (apo) AI but resulted in significant decreases cholesterol, triglycerides, low-density lipoprotein-cholesterol, apo B E, In contrast, increased. None these changes was influenced by polymorphisms. Overall, HDL-Lp-PLA change polymorphism its fluvastatin. Specifically, LL homozygotes experienced a increase, while M carriers (LM MM) non-significant decrease ( p = 0.030 between groups). Conclusions statin. modulated . It should noted that this an association study therefore provides no proof only indication exert HDL.