Abnormal FHIT expression profiles in cervical intraepithelial neoplastic (CIN) lesions.

摘要: Abnormal fragile histidine triad transcripts were found in 20-30% of CIN2/3 lesions and 11% normal cervical biopsies by RT-PCR. Bi-allelic loss the gene protein expression detectable immunochemical staining with a polyclonal specific antibody was rare. The genomic changes showed no association presence human papillomavirus types which carry high risk for cancer (high papillomavirus) as assessed type-specific multiplex PCR. abnormal subset suggests that this could be an independent factor associated alternative carcinogenic pathway.