T Cell-Derived Factors and Fibroblast-Derived Factors Regulate the Growth and Differentiation of Mast Cells

摘要: Mice and rats have distinct subpopulations of tissue mast cells that can be distinguished by their morphology, mediator content, cell surface phenotype. By studying the heterogeneity differentiation mouse rat using in vitro methods, we demonstrated skin-derived fibroblasts are essential for creating a microenvironment necessary maintaining viability phenotype connective (CTMC). On other hand, studies on bone marrow (BMMC), presumptive counterpart vivo mucosal (MMC), revealed T factor-dependent require IL-3 survival. In order to gain insight into possible pathways undertaken cells, BMMC been cocultured with cloned 3T3 fibroblasts. That these increase histamine ∼15-fold, become safranin+, synthesize heparin proteoglycans indicates induce change from resembling MMC more closely related CTMC. view which injected cell-deficient W/Wv mice also give rise histochemically resemble CTMC, our suggest anatomical will determine nature present any tissue.