Anti-Gal, α-Gal Epitopes, and Xenotransplantation

作者: Takaaki Kobayashi , David K. C. Cooper

DOI: 10.1007/978-1-4615-4771-6_10

关键词:

摘要: Significant progress in clinical transplantation has been achieved through the development of improved immunosuppressive therapy during past two decades. Transplantation is clearly established as treatment choice for many patients suffering from end-stage organ failure. Although number donors becoming available slowly increased, relative shortage caused by extended indications become critical. Attention now being focused on xenotransplantation—using animal organs, tissues or cells—as a potential and promising solution to this serious problem (Cooper, 1993a).

参考文章(182)
David K.C. Cooper, Xenoantigens and xenoantibodies. Xenotransplantation. ,vol. 5, pp. 6- 17 ,(1998) , 10.1111/J.1399-3089.1998.TB00003.X
Y. Xu, T. Lorf, T. Sablinski, P. Gianello, M. Bailin, R. Monroy, T. Kozlowski, M. Awwad, D. K.C. Cooper, D. H. Sachs, Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galalpha1-3Galbeta1-4betaGlc-X immunoaffinity column. Transplantation. ,vol. 65, pp. 172- 179 ,(1998) , 10.1097/00007890-199801270-00005
Launa J. Aspeslet, Patricia Chackowsky, Harbuksh Sekhon, Andrew J. Malcolm, Zina Mosleh, Arvind Koshal, Randall W. Yatscoff, Identification of porcine membrane antigens involved in the cytotoxic response mediated by human xenoreactive antibodies Xenotransplantation. ,vol. 3, pp. 1- 10 ,(1996) , 10.1111/J.1399-3089.1996.TB00112.X
U Galili, E A Rachmilewitz, A Peleg, I Flechner, A unique natural human IgG antibody with anti-alpha-galactosyl specificity. Journal of Experimental Medicine. ,vol. 160, pp. 1519- 1531 ,(1984) , 10.1084/JEM.160.5.1519
Bradley H. Collins, William Parker, Jeffrey L. Piatt, Characterization of porcine endothelial cell determinants recognized by human natural antibodies Xenotransplantation. ,vol. 1, pp. 36- 46 ,(1994) , 10.1111/J.1399-3089.1994.TB00048.X
Chihiro Koike, Reiji Kannagi, Yoshihiro Takuma, Fumiko Akutsu, Satoshi Hayashi, Nozomu Hiraiwa, Kenji Kadomatsu, Takashi Muramatsu, Hirohito Yamakawa, Takuya Nagai, Shoji Kobayashi, Hidechika Okada, Izumi Nakashima, Kazuharu Uchida, Itsuo Yokoyama, Hiroshi Takagi, Introduction of α(1,2)-fucosyltransferase and its effect on a-Gal epitopes in transgenic pig Xenotransplantation. ,vol. 3, pp. 81- 86 ,(1996) , 10.1111/J.1399-3089.1996.TB00123.X
U Galili, R E Mandrell, R M Hamadeh, S B Shohet, J M Griffiss, Interaction between human natural anti-alpha-galactosyl immunoglobulin G and bacteria of the human flora. Infection and Immunity. ,vol. 56, pp. 1730- 1737 ,(1988) , 10.1128/IAI.56.7.1730-1737.1988
Wanchun Shi, Yuhai Ma, A Novel Approach to ,(1996)
M. J. Tange, M. J. Pearse, A. J. F. d’Apice, Galα1–3Gal Xenoepitope: Donor-Targeted Genetic Strategies Springer Berlin Heidelberg. pp. 701- 713 ,(1997) , 10.1007/978-3-642-60572-7_51
D. K. C. Cooper, Y. Ye, L. L. Rolf, N. Zuhdi, The Pig as Potential Organ Donor for Man Xenotransplantation. ,vol. 57, pp. 481- 500 ,(1991) , 10.1007/978-3-642-97323-9_30