Circulating tumor cells as a prognostic and predictive marker in gastrointestinal stromal tumors: a prospective study

摘要: // Qiang Li 1, * , Xiaofei Zhi Jianping Zhou 2, Ran Tao 1 Jiaxuan Zhang Peisheng Chen Oluf Dimitri Roe 3, 4, 5 Luning Sun 6 Lilin Ma Department of General Surgery, Affiliated Hospital Nantong University, Nantong, China 2 Gastrointestinal Yixing Jiangsu Yixing, 3 Clinical Cancer Research Center, Aalborg University Hospital, Institute, Aalborg, Denmark 4 Clinic, Levanger Nord-Trondelag Health Trust, Levanger, Norway and Molecular Medicine, Norwegian Science Technology, Trondheim, Division Pharmacology, First Nanjing Medical Nanjing, These authors have contributed equally to this work Correspondence to: Ma, e-mail: mall9052@163.com Keywords: circulating tumor cells, ANO1, DOG1, gastrointestinal stromal tumors, recurrence Received: October 16, 2015     Accepted: April 2016     Published: May 2016 ABSTRACT Background: Circulating cells (CTC) are prognostic predictive for several cancer types. Only limited data exist regarding or impact CTC on (GIST) patients. The aim our study was elucidate the role in GIST Results: A total 121 patients 54 non-GIST samples were enrolled study. cutoff value ANO1 positive 3*10 -5 65 (54%) defined as positive. ANO1s more frequently detected unresectable Tumor size, mitotic count risk level associated with detection resectable presence significantly correlated poor disease-free survival (15.3 versus 19.6 months, p = 0.038). Most turned ANO1-negative after surgery inversely, all 21 ANO1-positive high expression levels. Moreover, neoadjuvant setting, decline response imatinib. Methods: Cells from peripheral blood mononuclear tested anoctamin calcium activated chloride channel, (DOG1) considered GISTs. levels determined using quantitative real-time polymerase chain reaction (qRT-PCR). highest used “cutoff” value. Conclusion: by qRT-PCR is clinical potential monitoring evaluating therapeutic efficacy imatinib