Prognostic factors for long term survival in patients with advanced non-small cell lung cancer

摘要: Background: Non-small cell lung cancer (NSCLC) represents 85% of all cancers. It is estimated that 60% patients with NSCLC at time diagnosis have advanced disease. The aim this study was to investigate clinical and demographic prognostic factors long term survival in unresectable NSCLC. Methods: We retrospectively reviewed data 1,156 stage IIIB or IV who survived more than 60 days from the treated August 1987 until March 2013 Oncology Department Pulmonary Clinic General Hospital Papanikolaou. Initially univariate analysis using log-rank test conducted then multivariate proportional hazards model Cox. Also Kaplan Meier curves were used describe distribution times patients. level significance set 0.05. Results: mean age 62 years. About 11.9% women 88.1% male. majority cases adenocarcinomas (42.2%), followed squamous (33%) finally large (6%). Unlike men, most common histological type among adenocarcinoma rather (63% vs. 10.9%). In statistically significant progression free (PFS) overall (OS) were: weight loss ≥5%, type, line 1 drugs, combination, cycles radio lung. Specifically gives clear benefit PFS OS (P=0.002) (P<0.001). On other hand, number distant metastases did not affect OS, neither PFS. addition received platinum taxane had better (P=0.001) (P<0.001) those without taxane. third drug administration proved futile, since (682.06±34.9) (P=0.023) (434.93±26.93) (P=0.012) less three drugs significantly larger. Finally, carcinoma recorded shortest compared (P=0.043 P=0.016 respectively) (P=0.021 P=0.004 respectively). same predictors except for drugs. Conclusions: This confirms increased incidence men aggressiveness carcinoma. also underlines vitality such as loss, doublet platinum-based. it excludes gender, smoking.