The Mechanisms of Androgen Effects on Body Composition: Mesenchymal Pluripotent Cell as the Target of Androgen Action

摘要: Testosterone supplementation increases muscle mass primarily by inducing fiber hypertrophy; however, the mechanisms which testosterone exerts its anabolic effects on are poorly understood. The prevalent view is that improves net protein balance stimulating synthesis, decreasing degradation, and improving reutilization of amino acids. However, synthesis hypothesis does not adequately explain testosterone-induced changes in fat mass, myonuclear number, satellite cell number. We postulate promotes commitment pluripotent stem cells into myogenic lineage inhibits their differentiation adipogenic lineage. primary site androgen action provides a unifying explanation for observed reciprocal mass.