Shank3-deficient rats exhibit degraded cortical responses to sound.
作者： Crystal T. Engineer , Kimiya C. Rahebi , Michael S. Borland , Elizabeth P. Buell , Kwok W. Im
DOI: 10.1002/AUR.1883
关键词:
摘要: Individuals with SHANK3 mutations have severely impaired receptive and expressive language abilities. While brain responses are known to be abnormal in these individuals, the auditory cortex response sound has remained largely understudied. In this study, we document speech non-speech sounds novel Shank3-deficient rat model. We predicted that would rats. found were weaker Shank3 heterozygous rats compared wild-type Additionally, had less spontaneous firing unable respond well rapid trains of noise bursts. The model impairments mutation could used test potential rehabilitation or drug therapies improve communication observed individuals Phelan-McDermid syndrome. Autism Res 2018, 11: 59-68. © 2017 International Society for Research, Wiley Periodicals, Inc. LAY SUMMARY abilities, yet control
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