Rho GTPases as therapeutic targets in cancer (Review)
作者： G.A. Cardama , N. Gonzalez , J. Maggio , P. Lorenzano Menna , D.E. Gomez
关键词:
摘要: Rho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In last few years, development genetic pharmacological tools has allowed a more precise definition specific roles in cancer. The aim present review is describe cellular functions regulated by these proteins with focus deregulated malignant tumors. Finally, we state art search different experimental therapeutic strategies as targets.
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