Metabonomics and drug development.
作者： Pranov Ramana , Erwin Adams , Patrick Augustijns , Ann Van Schepdael
DOI: 10.1007/978-1-4939-2377-9_14
关键词:
摘要: Metabolites as an end product of metabolism possess a wealth information about altered metabolic control and homeostasis that is dependent on numerous variables including age, sex, environment. Studying significant changes in the metabolite patterns has been recognized tool to understand crucial aspects drug development like efficacy toxicity. The inclusion metabonomics into OMICS study platform brings us closer define phenotype allows look at alternatives improve diagnosis diseases. Advancements analytical strategies statistical tools used allow prevent failures early stages reduce financial losses during expensive phase II III clinical trials. This chapter introduces along with instruments study; addition relevant examples usage process are discussed emphasis future directions challenges it faces.
springer.com
core.ac.uk
sci-hub.st 参考文章(54)
Jeremy K. Nicholson, Ian D. Wilson, Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism Nature Reviews Drug Discovery. ,vol. 2, pp. 668- 676 ,(2003) , 10.1038/NRD1157
Katja Dettmer, Pavel A. Aronov, Bruce D. Hammock, Mass spectrometry-based metabolomics. Mass Spectrometry Reviews. ,vol. 26, pp. 51- 78 ,(2007) , 10.1002/MAS.20108
J Yang, T Chen, L Sun, Z Zhao, X Qi, K Zhou, Y Cao, X Wang, Y Qiu, M Su, A Zhao, P Wang, P Yang, J Wu, G Feng, L He, W Jia, C Wan, Potential metabolite markers of schizophrenia Molecular Psychiatry. ,vol. 18, pp. 67- 78 ,(2013) , 10.1038/MP.2011.131
Ian D. Wilson, Jeremy K. Nicholson, Jose Castro-Perez, Jennifer H. Granger, Kelly A. Johnson, Brian W. Smith, Robert S. Plumb, High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. Journal of Proteome Research. ,vol. 4, pp. 591- 598 ,(2005) , 10.1021/PR049769R
Lee D. Roberts, Robert E. Gerszten, Toward New Biomarkers of Cardiometabolic Diseases Cell Metabolism. ,vol. 18, pp. 43- 50 ,(2013) , 10.1016/J.CMET.2013.05.009
Antonio Fabregat, Konstantinos Sidiropoulos, Phani Garapati, Marc Gillespie, Kerstin Hausmann, Robin Haw, Bijay Jassal, Steven Jupe, Florian Korninger, Sheldon McKay, Lisa Matthews, Bruce May, Marija Milacic, Karen Rothfels, Veronica Shamovsky, Marissa Webber, Joel Weiser, Mark Williams, Guanming Wu, Lincoln Stein, Henning Hermjakob, Peter D'Eustachio, The Reactome Pathway Knowledgebase. Nucleic Acids Research. ,vol. 44, pp. 472- 477 ,(2014) , 10.1093/NAR/GKV1351
C Geraldine McMahon, RoseAnne Kenny, Kathleen Bennett, Emrys Kirkman, Modification of acute cardiovascular homeostatic responses to hemorrhage following mild to moderate traumatic brain injury. Critical Care Medicine. ,vol. 36, pp. 216- 224 ,(2008) , 10.1097/01.CCM.0000295425.41831.85
J. Griffin, M. Bollard, Metabonomics: its potential as a tool in toxicology for safety assessment and data integration. Current Drug Metabolism. ,vol. 5, pp. 389- 398 ,(2004) , 10.2174/1389200043335432
Lee D Roberts, Albert Koulman, Julian L Griffin, Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome The Lancet Diabetes & Endocrinology. ,vol. 2, pp. 65- 75 ,(2014) , 10.1016/S2213-8587(13)70143-8
John C. Lindon, Elaine Holmes, Mary E. Bollard, Elizabeth G. Stanley, Jeremy K. Nicholson, Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis Biomarkers. ,vol. 9, pp. 1- 31 ,(2004) , 10.1080/13547500410001668379