The effects on neutral variability of recurrent selective sweeps and background selection

摘要: Levels of variability and rates adaptive evolution can be affected by hitchhiking, the effect selection on variants at linked sites. Hitchhiking caused either selective sweeps or background selection, involving spread new favorable alleles elimination deleterious mutations, respectively. Recent analyses population genomic data have fitted models where both these processes act simultaneously, in order to infer parameters selection. Here, we investigate consequences relaxing a key assumption some studies – that neutral site recurrent fully recovers between successive sweeps. We derive simple expression for expected level presence also approximate integral expressions effects given gene. The accuracy theoretical predictions was tested against multilocus simulations, using software SLiM with recombination mutation are realistic Drosophila melanogaster . find good agreement simulation results from approximations, except when crossing over close zero. show observed relations rate synonymous diversity largely reflect whereas needed produce substantial distortions frequency spectrum.