Bufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expression.
作者： Zhitu Zhu , Enze Li , Yangyang Liu , Yu Gao , Hongzhi Sun
DOI: 10.1159/000339424
关键词:
摘要: Background and Aims: Bufalin is a cardiotonic steroid isolated from the Chinese toad venom preparation Chan’su has been shown to induce leukemia cell differentiation apoptosis under certain experimental conditions. However, detailed mechanism by which bufalin induces of acute promyelocytic cells largely unexplored. Methods: The line NB4 was treated with bufalin, then proliferation evaluated viability assay detected flow cytometry analysis. In addition, were MEK inhibitor PD98059 in combination expression survivin activation caspase-3 Western blot Results: inhibited induced dose- time-dependent manner. Moreover, synergized inhibit cells, associated downregulation upregulation activation. Conclusions: potential regimen be used conventional chemotherapeutic drugs improve therapy.
sci-hub.se 参考文章(12)
S. Gail Eckhardt, Michael Carducci, Wells A. Messersmith, Manuel Hidalgo, Novel targets in solid tumors: MEK inhibitors. Clinical advances in hematology & oncology. ,vol. 4, pp. 831- 836 ,(2006)
Asmaa M. Esh, Maha Atfy, Nashwa A. Azizi, Mohamed M. El Naggar, Ebtesam E. Khalil, Layla Sherief, Prognostic Significance of Survivin in Pediatric Acute Lymphoblastic Leukemia Indian Journal of Hematology and Blood Transfusion. ,vol. 27, pp. 18- 25 ,(2011) , 10.1007/S12288-010-0053-Z
Chong-Wen Dai, Guang-Sen Zhang, Jian-Kai Shen, Wen-Li Zheng, Min-Fei Pei, Yun-Xiao Xu, Yi-Xiong Cao, Yan Yi, Jun-Jie Yang, Hong-Ling Peng, Hai-Ying Zhong, Rui-Juan Li, Use of All-trans Retinoic Acid in Combination with Arsenic Trioxide for Remission Induction in Patients with Newly Diagnosed Acute Promyelocytic Leukemia and for Consolidation/Maintenance in CR Patients Acta Haematologica. ,vol. 121, pp. 1- 8 ,(2009) , 10.1159/000204472
Leonidas C. Platanias, Map kinase signaling pathways and hematologic malignancies Blood. ,vol. 101, pp. 4667- 4679 ,(2003) , 10.1182/BLOOD-2002-12-3647
Tomohiko Kamimura, Toshihiro Miyamoto, Mine Harada, Koichi Akashi, Advances in therapies for acute promyelocytic leukemia Cancer Science. ,vol. 102, pp. 1929- 1937 ,(2011) , 10.1111/J.1349-7006.2011.02045.X
Nuria Barbarroja, Emilio Siendones, Luis Arístides Torres, Mª Jose Luque, Julio Manuel Martinez, Gabriel Dorado, Francisco Velasco, Antonio Torres, Chary López-Pedrera, MEK inhibition induces caspases activation, differentiation blockade and PML/RARα degradation in acute promyelocytic leukaemia British Journal of Haematology. ,vol. 142, pp. 27- 35 ,(2008) , 10.1111/J.1365-2141.2008.07154.X
Andreas Reiter, Eva Lengfelder, David Grimwade, Pathogenesis, diagnosis and monitoring of residual disease in acute promyelocytic leukaemia. Acta Haematologica. ,vol. 112, pp. 55- 67 ,(2004) , 10.1159/000077560
Qi-lian Liang, Bi-rong Wang, Guo-hong Li, DcR3 and survivin are highly expressed in colorectal carcinoma and closely correlated to its clinicopathologic parameters Journal of Zhejiang University SCIENCE B. ,vol. 10, pp. 675- 682 ,(2009) , 10.1631/JZUS.B0920077
M. Germana Sanna, Jean da Silva Correia, Odile Ducrey, Jongdae Lee, Ken Nomoto, Nicolas Schrantz, Quinn L. Deveraux, Richard J. Ulevitch, IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition. Molecular and Cellular Biology. ,vol. 22, pp. 1754- 1766 ,(2002) , 10.1128/MCB.22.6.1754-1766.2002
Ailiang Chen, Jian Yu, Liang Zhang, Yimin Sun, Yan Zhang, Hongyan Guo, Yuxiang Zhou, Keith Mitchelson, Jing Cheng, Microarray and biochemical analysis of bufalin-induced apoptosis of HL-60 Cells Biotechnology Letters. ,vol. 31, pp. 487- 494 ,(2009) , 10.1007/S10529-008-9888-X