Autoregulation in hypertension: a review.

摘要: The hypothesis examined here is that autoregulation of peripheral flow the dominant factor in initiating and maintaining rise resistance hypertension. Vascular smooth muscle possesses myogenic activity, which dependent upon wall tension thus intravascular pressure, but activity modulated by metabolic factors are flow-dependent. Autoregulation microvessels considered to be a reflection wider concept tissue or cellular oxygen through control delivery extraction relation consumption. Indirect evidence for hypothesis, involving measurement consumption both whole body defined regions various forms hypertension, discussed. Individual species differences type response changes dependence/independence on may account some discrepant observations. Specific criticisms discussed it concluded balance indirect supports hypothesis. Lastly, if indeed involved development constitutes only part complex pathogenic mechanism, whose major role maintain sodium water body.