Utility of tumour markers in the diagnosis of neoplastic pleural effusion

摘要: Abstract Approximately 20% of pleural effusions are caused by neoplastic processes. Although cytology is the most specific routine diagnostic procedure, its sensitivity 50–60% insufficient, and thus diagnosis usually carried out more invasive techniques such as biopsy, thoracoscopy or thoracotomy. The object this study to evaluate use determining some tumour markers in fluid obtained thoracocentesis for effusion. Patients (271) with were classified five groups: I: neoplasms n = 88; II: tuberculosis 63; III: parapneumonics 53; IV: miscellaneous exudates 39 V: transudates 28. studied were: carcinoembryonic antigen (CEA), CA 125, squamous cell carcinoma (SCC), neuron enolase (NSE). makers had following efficiencies origin effusion: CEA 76% (sensitivity 31%, specificity 93%); 125 66% (70% 61%); SCC 65% (48% 80%) NSE 53% (30% 89%). pulmonary origins 68% 83%, 53%); (54% 75%); 63% (80% 48%) 61% (79% 42%). We believe that testing would greatly increase effectiveness could avoid practice aggressive on patient.