Mechanisms of Quinolone Resistance

摘要: With the increasing use of quinolones for treatment gram-positive bacterial infections, an understanding mechanisms quinolone resistance in bacteria is considerable importance. This chapter summarizes current established to this class antimicrobial agents bacteria. There are important differences between and gram negative both target enzyme sensitivity means by which efflux operate that clinical fundamental Quinolones interact with two type 2 topoisomerases eubacteria, DNA gyrase topoisomerase IV, essential replication. Quinolone-resistant laboratory strains Streptococcus pneumoniae have been shown reduced accumulation reversible reserpine, suggesting involvement system(s) resistance. isolates viridans streptococci phenotype defined as lower MICs presence reserpine. from such S. mitis oralis was able transform laboratory. Overexpression norA genes plasmids known, however, toxic effects on cell may limit fitness resistant containing them. Thus, at present attributable exclusively chromosomal mutations affect targets or permeation these targets.