Co-ultra PEALut enhances neuronal recovery after a moderate traumatic brain injury

摘要: Traumatic brain injury (TBI) is a major health problem worldwide. Currently, there no effective treatment to improve neural structural repair and functional recovery. Recently, has been demonstrated that hippocampal injury-induced neurogenesis one mechanism underlying endogenous following TBI. The aim of this study was evaluate the neuro-regenerative properties co-ultra PEALut (constituted by association palmitoylethanolamide (PEA), with flavonoid luteolin (Lut)) in mouse model TBI until 7 days. induced mice controlled cortical impact (CCI), most common models TBI; were orally administered (1mg/Kg) 1h after trauma daily for 72h 7d. A conspicuous seen 7d trauma. Co-ultra stimulated neuronal reconstitution process restoring basal level new neurons (by BrdU staining) mature doublecortin staining). Moreover positive effect associated an important upregulation neurotrophic factors (BDNF NT-3), ultimately leading improvement memory recall on behavioral testing (Morris water maze test). could represent therapeutic potential augmenting response treating